Our BMO kits enable, in three simple steps, synthesis of metabolites directly from the parent drug.
HepatoChem has developed a revolutionary way to screen, optimize, and produce metabolites directly from drug candidates. The BMO Kit exploits an optimized panel of catalytic chemical reaction conditions using organometallic catalysts in a multi-well parallel format. This tool mimics the suite of cytochrome P450 enzymes (CYP) present in human hepatocytes, offering the researcher a unique synthetic chemical liver.
Exciting new technology speeds up metabolite study:
- Produce drug metabolites in days, not months.
- Exclusive process produces large quantities of metabolites.
- Rapid, inexpensive scale up for NMR and
- Eliminate complex and costly synthetic chemistries.
- Easy to implement – compatible with any existing workflow.
Our innovative approach is based on a diverse panel of chemical conditions that
The HepatoChem tool, basically a chemical liver, is analogous to the panel of cytochromes P450 present in the human liver, but with the advantage of the scalability of chemistry. When a reaction condition is identified, it is optimized and scaled up to produce mg quantities of metabolites. Our series of easy-to-use kits
Possible Biotransformation Reactions:
- Aliphatic Hydroxylation
- N- and
- N- and S-Oxidation
- Cleavage and rearrangement
BMO™ Biomimetic Oxidation Kits
Cat #: HCK1001-01-001
Cat #: HCK1001-02-xxx
Cat #: HCK1001-03-xxx
|Step 1: Perform the primary screen. Select desired metabolite wells. Order corresponding optimization kit.||Step 2: Perform the optimization kit. Identify
||Step 3: Scale-up and isolate your metabolite.