Sulfinate Alkylation Diversification Kits:
HCK1013-01-001
HCK1013-01-002
Product overview:
The sulfinate alkylation reaction described by Prof. Baran is a powerful |
6 Different Diversification Groups
|
||||||||||||||||||||||||||||||||||||||||||||||||
|
Sulfinate Alkylation 6X Reagents (2 Vials of each)
|
|||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
||||||||||||||||||||||||||||||||||||||||||||||||
HCK1013-01-001 |
HCK1013-01-002 |
||||||||||||||||||||||||||||||||||||||||||||||||
|
|
||||||||||||||||||||||||||||||||||||||||||||||||
|
Standard Protocol: Several solvents or solvent mixtures can be used to perform the reaction (DMSO, DMSO/H2O/TFA, CHCl3/H2O/TFA… ). A solution of
|
Standard Protocol: Several solvents or solvent mixtures can be used to perform the reaction (DMSO, DMSO/H2O/TFA, CHCl3/H2O/TFA… ). A solution of
|
||||||||||||||||||||||||||||||||||||||||||||||||
| Sulfinate Alkylation Reagents (2 Vials of each) | ||||||
| Zinc difluoro methane sulfinate | Zinc trifluoro methane sulfinate | Sodium 1,1- |
Zinc |
Zinc isopropyl sulfinate | Sodium trifluoro propyl |
|
 |
 |
 |
 |
 |
 |
|
| MW (g/mol) | 295.55 | 331.53 | 152.10 | 359.58 | 279.69 | 184.11 |
| CAS Number | 1355729-38-2 | 39971-65-8 | 1422738-67-7 | 1416821-53-8 | 1416821-55-0 | 1263377-91-8 |
Sulfinate Alkylation Solvent Effect |
|
|
Substrate:
|
 |
|
|
|
 |
 |
HCK1013-01-001
The typical protocol is performed at 0.142 mol/l concentration reaction condition. 2 equivalents of sulfinate reagent are preloaded (100 µmol) and 3 equivalents of TBHP is added. These reaction conditions
Recommended solvents are DMSO or CHCl3 with or without H2O/TFA (0.1 ml of TFA in 2 ml of water). H2O/TFA can change the regioselectivity and conversion of the reaction.
- Prepare a solution of
substrate with 300 µmol ofsubstrate in 2.1 ml selected solvent. - Add 350 µl of substrate solution to each reagent vial containing the
sulfinates . Shake the vial to allow reagents to mix properly. - If needed add 80 µl of H2O/TFA in each vial.
- Add 21 µl of TBHP in each vial.
- Stir the reaction vials in the reaction block at 50°C for 12-24 hours.
- Remove the vial caps.
- Prepare
analytical sample for each reaction condition with 5 µl sample diluted into 200 µl in either DMSO or water/acetonitrile 50/50.
Analyze resulting analytical samples by LC/MS.
HCK1013-01-002
The typical protocol is performed at 0.142 mol/l concentration reaction condition. 2 equivalents of sulfinate reagent are preloaded (10 µmol) and 3 equivalents of TBHP is added. These reaction conditions
Recommended solvents are DMSO or CHCl3 with or without H2O/TFA (0.1 ml of TFA in 2 ml of water). H2O/TFA can change the regioselectivity and conversion of the reaction.
- Prepare a solution of
substrate with 30 µmol ofsubstrate in 210 µl selected solvent. - Add 35 µl of substrate solution to each reagent vial containing the
sulfinates . Shake the vial to allow reagents to mix properly. - If needed add 8 µl of H2O/TFA in each vial.
- Add 2.1 µl of TBHP in each vial.
- Stir the reaction vials in the reaction block at 50°C for 12-24 hours.
- Remove the vial caps.
- Prepare
analytical sample for each reaction condition with 5 µl sample diluted into 200 µl in either DMSO or water/acetonitrile 50/50.
Analyze resulting analytical samples by LC/MS.
Request Form
Interested in learning more about our products?
Complete our request form and we’ll get back to you as soon as possible.
