Photoredox Synthesis of Arylhydroxylamines from Carboxylic Acids and Nitrosoarenes


Hydroxylamines are found in biologically active compounds and serve as building blocks for the preparation of nitrogen-containing molecules. Here the direct conversion of carboxylic acids into the corresponding alkylhydroxylamines using organo-photoredox catalysis is reported. The process relies in the generation of alkyl radicals via photoinduced oxidation-decarboxylation and their following reaction with nitrosoarenes. We have successfully applied this method to the late-stage modification of complex and biologically active acids and applied it in novel radical cascade processes.

Authors: Jacob Davies, Lucrezia Angelini, Mohammed A. Alkhalifah, Laia Malet Sanz, Nadeem S. Sheikh*, Daniele Leonori  *


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