Photoreactors, LEDs & Accessories
Photochemistry is a powerful tool for chemical synthesis and a variety of conditions have been reported in the scientific literature using a wide range of catalysts and reagents. Therefore HepatoChem offers a number of proprietary and advanced photoreactors as well as a number of screening kits and accessories to explore photochemical conditions.
Our original photoreactor, this patented device is compatible with most vial formats (0.3 ml, 2 ml, 4 ml and 20 ml vials) and is compatible with most stirring plates. A built-in fan keeps the reaction conditions at room temperature. Several light source options are available.
The PhotoRedOx Duo uses the same unique design as our original photoreactor but doubles the vial capacity and includes an additional reaction chamber. The photoreactor Duo can hold up to 16 vials (2, 4 or 8 ml) and can accommodate a second light source for increased reaction rates of difficult reaction conditions.
Also based on our original photoreactor, the TC version, with a standard chiller/heater unit (not included), makes possible to perform photo-catalytic reactions at controlled temperatures from 0°C to 80°C.
Our specially designed flow reactor (meant to be used with our PhotoRedOx Box) enables scaling of photochemistry reactions by significantly increasing surface area. This flow reactor uses PFA tubing and has volume of 2 ml.
Accessories & Literature
Research Publications Featuring Photochemistry
Visible Light-Induced Regioselective Cycloaddition of Benzoyl Azides and Alkenes To Yield Oxazolines
Abstract: Visible light catalysis allows the regioselective synthesis of oxazolines in high yields. The mild photosensitized manifold leverages the intermolecular formation of oxazolines with a wide functional group tolerance on both benzoyl azides and alkenes partners. Mechanistic investigations suggest the sensitization of the azide moiety as the key activation step.
Visible-Light-Induced Trifluoromethylation of Unactivated Alkenes with Tri(9-anthryl)borane as an Organophotocatalyst
Abstract: Tri(9-anthryl)borane was successfully applied as an organophotocatalyst for the visible-light-induced trifluoromethylation of unactivated alkenes with CF3I. The mild reaction conditions tolerated a variety of functional groups, and the reaction could be extended to perfluoroalkylations with C3F7I and C4F9I. Mechanistic studies revealed that the photoredox catalysis involves an oxidative quenching pathway.
Here we report the first such use of photoredox catalysis to promote the addition of organic halides to the caged carbocycle [1.1.1]propellane; the products of this process are bicyclo[1.1.1]pentanes (BCPs), motifs that are of high importance as bioisosteres in the pharmaceutical industry, and in materials applications.
Abstract: A quinone-mediated general synthetic platform for the construction of primary α-tertiary amines from abundant primary α-branched amine starting materials is described. This procedure pivots on the efficient in situ generation of reactive ketimine intermediates and subsequent reaction with carbon-centered nucleophiles such as organomagnesium and organolithium reagents, and TMSCN, creating quaternary centers.
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