Photoreactors-LEDs-Accessories

Photoreactors, LEDs & Accessories

 

Photochemistry is a powerful tool for chemical synthesis and a variety of conditions have been reported in the scientific literature using a wide range of catalysts and reagents. Therefore HepatoChem offers a number of proprietary and advanced photoreactors as well as a number of screening kits and accessories to explore photochemical conditions.

Photoreactors

photoreactor

PhotoRedOx Box

Our original photoreactor, this patented device is compatible with most vial formats (0.3 ml, 2 ml, 4 ml and 20 ml vials) and is compatible with most stirring plates. A built-in fan keeps the reaction conditions at room temperature.  Several light source options are available.

photoredox duo photoreactor

PhotoRedOx Box Duo

The PhotoRedOx Duo uses the same unique design as our original photoreactor but doubles the vial capacity and includes an additional reaction chamber. The photoreactor Duo can hold up to 16 vials (2, 4 or 8 ml) and can accommodate a second light source for increased reaction rates of difficult reaction conditions.

Temperature controlled photoreactor

PhotoRedOx Box TC (Temp Controlled)

Also based on our original photoreactor, the TC version, with a standard chiller/heater unit (not included), makes possible to perform photo-catalytic reactions at controlled temperatures from 0°C to 80°C.

Flow Photoreactor

PhotoRedOx Flow Reactor

Our specially designed flow reactor (meant to be used with our PhotoRedOx Box) enables scaling of photochemistry reactions by significantly increasing surface area.  This flow reactor uses PFA tubing and has volume of 2 ml. 

 

Photochemistry Screening Kits

Research Publications Featuring Photochemistry

Photocatalytic α‐Tertiary Amine Synthesis via C–H Alkylation of Unmasked Primary Amines

AbstractA practical, catalytic entry to α,α,α‑trisubstituted (α‑tertiary) primary amines by C–H functionalisation has long been recognised as a critical gap in the synthetic toolbox. We report a simple and scalable solution to this problem that does not require any in situ protection of the amino group and proceeds with 100% atom‐economy. 

Visible Light-Induced Regioselective Cycloaddition of Benzoyl Azides and Alkenes To Yield Oxazolines

Abstract: Visible light catalysis allows the regioselective synthesis of oxazolines in high yields. The mild photosensitized manifold leverages the intermolecular formation of oxazolines with a wide functional group tolerance on both benzoyl azides and alkenes partners. Mechanistic investigations suggest the sensitization of the azide moiety as the key activation step.

Carbon-Heteroatom Cross-Coupling via an Electronically Excited Nickel (II) Complex

Reported here is a method that allows for C-O, C-N and C-S cross coupling reactions under one general methodology. We propose that an energy transfer pathway, in which an iridium photosensitizer produces an excited nickel (II) complex, is responsible for the key reductive elimination step that couples aryl halides to 1° and 2° alcohols, anilines, thiophenols, carbamates and sulfonamides.

Visible-Light-Induced Trifluoromethylation of Unactivated Alkenes with Tri(9-anthryl)borane as an Organophotocatalyst

Abstract: Tri(9-anthryl)borane was successfully applied as an organophotocatalyst for the visible-light-induced trifluoromethylation of unactivated alkenes with CF3I. The mild reaction conditions tolerated a variety of functional groups, and the reaction could be extended to perfluoroalkylations with C3F7I and C4F9I. Mechanistic studies revealed that the photoredox catalysis involves an oxidative quenching pathway.

Visible Light Promoted Functionalisation of Carbon-Carbon Sigma Bonds

Here we report the first such use of photoredox catalysis to promote the addition of organic halides to the caged carbocycle [1.1.1]propellane; the products of this process are bicyclo[1.1.1]pentanes (BCPs), motifs that are of high importance as bioisosteres in the pharmaceutical industry, and in materials applications.

photocatalysis in seawater
Photocatalysis in Seawater

Seawater: It’s abundant, messy, contains salts, microorganisms, biomass, organic and inorganic pollutants (and microplastics) and might just be a great solvent for generating hydrogen peroxide with visible light photocatalysis

Comparing Commercial Photoreactors
When is an apple an apple or when is it an orange? How should we compare commercial photoreactors?  Or better yet, how do we discuss the important details of a...
The 21 Must-Read Photochemistry Papers of 2021
A belated year in review 2021 At HepatoChem, we had a big year in 2021. We started shipping our new photoreactor the Lucent360™, added members to our team, moved...
Utilizing the Lucent360 from screen to scale
A few weeks ago, we discussed the history of the Lucent360™, our new photoreactor for light and temperatures control for screen to scale, in both batch and flow....
Introducing the Lucent360 TM
A Brief History of a PhotoReactor We write from time to time here about the topics that we find interesting or humorous in the photoredox, visible-light photocatalysis...
Photochemistry of earth-abundant metals
A recurring theme for many of our articles over the last few months is that there just isn’t enough iridium or ruthenium in the earth’s crust to do all of the...
The Attack of the Photocatalytic Microrobots!
The attack of the photocatalytic microrobots! We have intended to write a bit about visible-light decomposition of contaminants for a while... so what better entry into...
Using Multiphoton Excitation To Generate Potent Photooxidants
A New Potent Photooxidant Pushing the limits of LED driven visible-light photocatalysis requires some creative thinking to get more redox potential out of the tools...
Petal Power: Organic Dyes in Photochemistry
Potpourri Catalysis – Fascinating Photoredox Chemistry With Organic Dyes
Spring is nearly here in Massachusetts.  The snow has almost completely melted, and the days are getting longer.  Soon the first flowers will bloom and some of those...
sarcastic 2020 logo
The 20 Must Read Photochemistry Papers from 2020
Year in review 2020.  Let’s all agree to not look back.  20 papers for 2020 As the year comes to the close, we thought it was time to have a little fun and look back at...
Photochemistry 101, Part III: Setting Up Your Initial Photochemistry Reactions
Setting Up Your Initial Photochemistry Reactions This is the third and final part of a three part series designed to help you get started by understanding light sources...

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