PhotoReactor Setup

Interest in photochemistry has been growing exponentially in recent years. Numerous new applications using visible-light photoredox catalysis have been discovered. These catalytic systems can perform many types of bond formations using various substrates which are...

How do you handle hygroscopic salts?

Salts such as weak bases are omnipresent in organic chemistry. The conversion rate of a reaction can be greatly affected depending on the salt. While it is easy to weigh K2CO3 or Na2CO3, salts such as Cs2CO3 or K3PO4 are more difficult to handle when the reaction...

ACS Expo 2016 August 21st-23rd

ACS Expo 2016 August 21st-23rd Please come visit HepatoChem Booth #338 at the 252nd American Chemical Society National Meeting & Exhibition to discover our new catalog of chemistry kits.   Late stage functionalization kits Alkoxylation and Acetoxylation Kits...

Amide Coupling in Medicinal Chemistry

In recent years, amide coupling has become the most frequently used reaction in medicinal chemistry1.  Found as the backbone of proteins, the amide bond is nominal formed by the condensation of a carboxylic acid and an amine.  Due to a nearly unlimited set of readily...

Magic methyl in medicinal chemistry

Methyl groups are very common in drug molecules. As reported by Heike Schonherr and Tim Cernak1, more than half of the top-selling drugs contains a CH3. A simple substitution of a C-H with a methyl can increase the potency of a compound by more than 100-fold. The...

Buchwald palladium precatalysts

Palladium based catalysis is the most used tool to perform the formation of C-C, C-O and C-N. There are many sources of palladium such as PdOAc2, PdCl2 or Pd2dba3. However the related methods do not always allow sufficient conversion. Palladium precatalysts is an...

HepatoChem Presenting at the ACS Meeting in Boston, MA

Dr Ryan Buzdygon will be presenting “Late-stage functionalization platform for lead optimization and diversification: Generation of high value compounds directly for biological testing” at ACS Boston. Stop by on Wednesday August 19th during the General Posters Session...