Glucuronidation Reagent Kit
The EvoluChem Glucuronidation reagent kit allows to easily identify a reaction condition that produces O or N glucuronide adduct of a drug compound. The reaction conditions are derivative of the Koenigs–Knorr reaction.
Please note that this kit does not allow for acyl glucuronide production.
This is a 2 step process:
1) Coupling with glucuronidation reagent: The first step is performed at either 25C or 0C with 4 different salts including silver salts and 2 different solvents.
2) De-protection with NaOH/MeOH solution : The second step consists of de-protecting the intermediate using NaOH/MeOH solution or LiOH/MeOH solution.
List of kits
Glucuronidation array kit (10 reaction conditions) to generate O or N
glucuronide metabolite. This kit includes 2 set of reagents.
Catalogue Ref #: HCK1002-01-001
Starter kit (needed to perform glucuronidation kit)
This kit contains 1 reaction block (24x 2ml vial, 32X 0.3ml vial, 4X 2Dram vial), 1 decapper for 8 mm crimped vial and 1 syringe.
Catalogue Ref #: HCK1006-01-001
Glucuronidation Optimization Kit
Optimization array kit (4 reaction conditions) to generate O or N
Catalogue Ref #: HCK1002-02-xxx
Glucuronidation Production Kit
Production kit to generate O or N glucuronide metabolite at 12.5 µmol
scale. This kit includes 4 refill of reagents.
Catalogue Ref #: HCK1002-03-xxx