Glucuronidation Reagent Kit

The EvoluChem Glucuronidation reagent kit allows to easily identify a reaction condition that produces O or N glucuronide adduct of a drug compound. The reaction conditions are derivative of the Koenigs–Knorr reaction.

Please note that this kit does not allow for acyl glucuronide production.

This is a 2 step process:

1) Coupling with glucuronidation reagent: The first step is performed at either 25C or 0C with 4 different salts including silver salts and 2 different solvents.

2) De-protection with NaOH/MeOH solution : The second step consists of de-protecting the intermediate using NaOH/MeOH solution or LiOH/MeOH solution.

List of kits

Glucuronidation kit

Glucuronidation array kit (10 reaction conditions) to generate O or N
glucuronide metabolite. This kit includes 2 set of reagents.

Catalogue Ref #: HCK1002-01-001

Starter kit (needed to perform glucuronidation kit)

This kit contains 1 reaction block (24x 2ml vial, 32X 0.3ml vial, 4X 2Dram vial), 1 decapper for 8 mm crimped vial and 1 syringe.

Catalogue Ref #: HCK1006-01-001

Glucuronidation Optimization Kit

Optimization array kit (4 reaction conditions) to generate O or N
glucuronide metabolite.

Catalogue Ref #: HCK1002-02-xxx

Glucuronidation Production Kit

Production kit to generate O or N glucuronide metabolite at 12.5 µmol
scale. This kit includes 4 refill of reagents.

Catalogue Ref #: HCK1002-03-xxx