Suzuki-Miyaura Cross-Coupling Screening Kits

Description:

Our Suzuki-Miyaura Cross-Coupling Screening Kits are designed to conveniently investigate multiple reactions simultaneously. Suzuki-Miyaura reactions have been reported in the literature using a wide range of catalysts and reagents. Consequently, often these reactions are highly substrate, solvent and base specific. When a first attempt is unsuccessful, the endless combination of reagent make the research of optimum reaction conditions overwhelming. In order to facilitate the screening of common Suzuki-Miyaura reaction conditions, HepatoChem has released a series of high-throughput reaction screening kits combining common palladium sources, ligands and bases combinations to achieve successful cross-coupling transformations.

Suzuki-Miyaura Cross-Coupling Screening Kits Protocol

The standard protocol is performed with 100 µl  substrates solution at 0.15M concentration, 10% catalyst and 2 equivalents of base. Additional conditions can be investigated by changing substrate concentration, amount of base. you can choose between 2 different arrays of catalysts and between aquous solution of bases or solid anhydrous bases.

1.  Prepare the substrate solution.
2. Add to reaction vials containing the pre-weighed reagents and catalysts using a syringe.

3. Place the reaction block on a standard stir/heat plate and set your reaction temperature.

 

4 Suzuki-Miyaura Screening Kits Available

2 Kits are available with a array format of 8 catalysts and 8 bases.

The kit HCK1003-01-001 contains bases in aqueous solution.

The kit HCK1003-01-005 contains solid anhydrous bases premixed with the catalysts.

2 Kits are available with a array format of 8 catalysts and 8 bases.

The kit HCK1003-01-002 contains bases in aqueous solution.

The kit HCK1003-01-003 contains solid anhydrous bases premixed with the catalysts.

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