Photo-Catalytic Alkylation Production Kit
The trifluoroborate alkylation reaction (Minisci reaction) described by Prof. Molander is a powerful
Photo-catalytic alkylation production kit using 8 different alkylation reagents in 50
The typical protocol is performed at 0.1 mol/l of
substrate prepared as solution in DMSO or H2O/ACN with 5 equiv. of trifluoroacetic acid.
Each sealed reaction vial contains either 75 µmol of BF3K reagent with 100 µmol of K2S2O8 or 250 µmol of
Protocol at 500 µl volume reaction condition
- In the vial provided containing the Ir catalyst, prepare 4.0 ml of substrate solution at 0.1 mol/L of
substrate(400 µmol substrateneeded) in either DMSO or H2O/ACN with 153 µL of trifluoroacetic acid (5 equiv.). Mix thoroughly.
- Degas the substrate/catalyst solution with subsurface sparging via N2 or Ar line with exit needle for 5 minutes.
- Using a clean and dry syringe, add 500 µL of the substrate solution to each reaction vial (8 reactions).
- Place samples in vial holder HCK1006-01-018.
- Turn on
lamp(6200K white LED or blue LED 450 nm) and stir vials for 2 to 4 hours (or longer if necessary and there is substrate remaining). Be sure to plug in fan to maintain RT.
- Upon completion of
reaction, prepare analyticalsample for each reaction condition with 5 µl sample diluted into 200 µl in either DMSO or water/acetonitrile 50/50.
Analyze resulting analytical samples by LC/MS.