Fluorination is one of the most interesting C-H functionalization described in
Kit Contains PdOAc2 with either AgF,
Protocol: The typical protocol is performed at 0.05 mol/l concentration of substrate with four different fluorinating agents. When present, reaction includes 10 mol% catalyst and 2
The typical protocol is performed at 0.05 mol/l concentration of substrate with four different fluorinating agents. When present, reaction includes 10 mol% catalyst and 2
Each kit contains two sets of reagents allowing the screening of two different solvents. Preferred solvents for the fluorination kit include a 5% isobutyronitrile (iPrCN)/dichloroethane mixture, dichloroethane, acetonitrile
If low solubility of
Protocol at 50 µl volume reaction condition
requiredvolume of a 0.05 mol/L solution of substrate in reactionsolvent. For example, 700 µl solution for 12 reaction conditions (100 µl extra to compensate potential evaporation). If solubilityof the substrate is an issue, refer to tablebelow.
- Using a clean and dry syringe, add 50 µl of substrate solution to each vial.
- Stir the reaction vials in the reaction block at
desiredtemperature (for 60°C) for 12-24 hours. example:
- Remove the vial caps using a
analyticalsample for each reaction condition with 5 µl sample diluted into 200 µl in either DMSO or water/acetonitrile 50/50.
Analyze resulting analytical samples by LC/MS.
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