Suzuki-Miyaura HCK1003-01-003

Suzuki Miyaura Cross Coupling:
Anhydrous Base Kit
(HCK1003-01-003)

1 set of 8 catalysts (Pd(PPh3)4, Pd(dppf)2Cl2, PdOAc2/Sphos, PdOAc2/Xphos, Pd2(dba)2/Sphos, Pd2(dba)3/XPhos, Pd(OAc)2/CataCXium® and Pd(Amphos)Cl2) premixed with 4 anhydrous bases (Na2CO3, K2CO3, K3PO4, and  Cs2CO3). 24 reaction conditions.

This kit requires EvoluChem reaction block (HCK1006-01-002) included in the EvoluChem Starter Kit (HCK1006-01-001).

The typical protocol is performed at 0.15 mol/l concentration reaction condition and 1 to 1 ratio boronic acid reagent and halogenated substrate in 100 µl selected solvent. Resulting catalyst loading is 10%. Each vial contains 2 equiv. of base. However, it is possible to investigate different substrate ratios and concentrations. Maximum volume for reaction condition is 250 µl.

Protocol at 100 µl volume reaction condition

  • Prepare required volume of a 0.15 mol/L solution of combined substrates (boronic acid reagent and halogenated substrate) in the selected solvent. For example, 450 µl solution for 4 reaction conditions (extra 50 µl for evaporation).
  • For best results sparge solvents with N2 or Ar before addition to reaction vials.
  • Using a clean and dry syringe, add 100 µl of substrates solution to a reaction vial and mix with the catalysts using the syringe.
  • Stir the reaction vials in the reaction block at desired temperature (for example: 80°C) for 3 to 12 hours.
  • Remove the vial caps using a decapper.
  • Prepare analytical sample for each reaction condition with 5 µl sample diluted into 200 µl in either DMSO or water/acetonitrile 50/50.
  • Analyze resulting analytical samples by LC/MS.

photocatalysis in seawater
Photocatalysis in Seawater

Seawater: It’s abundant, messy, contains salts, microorganisms, biomass, organic and inorganic pollutants (and microplastics) and might just be a great solvent for generating hydrogen peroxide with visible light photocatalysis

Comparing Commercial Photoreactors
When is an apple an apple or when is it an orange? How should we compare commercial photoreactors?  Or better yet, how do we discuss the important details of a...
The 21 Must-Read Photochemistry Papers of 2021
A belated year in review 2021 At HepatoChem, we had a big year in 2021. We started shipping our new photoreactor the Lucent360™, added members to our team, moved...
Utilizing the Lucent360 from screen to scale
A few weeks ago, we discussed the history of the Lucent360™, our new photoreactor for light and temperatures control for screen to scale, in both batch and flow....
Introducing the Lucent360 TM
A Brief History of a PhotoReactor We write from time to time here about the topics that we find interesting or humorous in the photoredox, visible-light photocatalysis...
Photochemistry of earth-abundant metals
A recurring theme for many of our articles over the last few months is that there just isn’t enough iridium or ruthenium in the earth’s crust to do all of the...
The Attack of the Photocatalytic Microrobots!
The attack of the photocatalytic microrobots! We have intended to write a bit about visible-light decomposition of contaminants for a while... so what better entry into...
Using Multiphoton Excitation To Generate Potent Photooxidants
A New Potent Photooxidant Pushing the limits of LED driven visible-light photocatalysis requires some creative thinking to get more redox potential out of the tools...
Petal Power: Organic Dyes in Photochemistry
Potpourri Catalysis – Fascinating Photoredox Chemistry With Organic Dyes
Spring is nearly here in Massachusetts.  The snow has almost completely melted, and the days are getting longer.  Soon the first flowers will bloom and some of those...
sarcastic 2020 logo
The 20 Must Read Photochemistry Papers from 2020
Year in review 2020.  Let’s all agree to not look back.  20 papers for 2020 As the year comes to the close, we thought it was time to have a little fun and look back at...
Photochemistry 101, Part III: Setting Up Your Initial Photochemistry Reactions
Setting Up Your Initial Photochemistry Reactions This is the third and final part of a three part series designed to help you get started by understanding light sources...

Contact Us

Interested in learning more about our products?

Complete our short contact form and we’ll get back to you as soon as possible.

Stay up-to-date!
Get insights and tips from experts