Buchwald Cross-Coupling HCK1004-01-003

Buchwald Cross Coupling Array:
Pd Amination Weak Base Array
(HCK1004-01-003)

2 sets of 10 reagent combinations in separated vials; 5 Catalysts (BrettPhosG2, RuPhosG2, XPhosG2, tBuXPhosG3 and tBuBrettG3) and 2 bases (NaOtBu and LHMDS) 20 reaction vials total.

This kit requires EvoluChem reaction block (HCK1006-01-002) included in the EvoluChem Starter Kit (HCK1006-01-001)

The typical protocol is performed at 0.15 mol/l concentration reaction condition and 1 to 1 ratio substrates in 100 µl selected solvent. Resulting catalyst loading is 10%. Two equivalents of base are preloaded (30 µmol). It is possible to decrease substrate concentration by increasing the reaction volume (see chart below). Maximum volume for reaction condition is 250 µl. Recommended solvents are dioxane, tBuOH or Toluene.

Protocol at 100 µl volume reaction condition

  • Prepare required volume of a 0.15 mol/L solution of combined substrates in the desired sparged solvent. For example, 1100 µl solution for 10 reaction conditions (100 µl extra to compensate potential evaporation).
  • Using a clean and dry syringe, add 100 µl of substrates solution to each reagent vial containing a precatalyst. Stir to dissolve the precatalyst.
  • Transfer content of the precatalyst vial to a reaction vial containing a strong base.
  • Stir the reaction vials in the reaction block at desired temperature (for example: 80°C) for 3 to 12 hours.
  • Remove the vial caps using a decapper.
  • Prepare analytical sample for each reaction condition with 5 µl sample diluted into 200 µl in either DMSO or water/acetonitrile 50/50. Analyze resulting analytical samples by LC/MS.

Lucent 360, photoredox, C-N couplings
Lucent360 Customized Reaction Screenings

Learn how to streamline with Lucent360 customized reaction screenings and save on time & setups when matching optimal wavelength to a photocatalyst.

Upcycling Plastic Using Light
Photocatalytic Deconstruction of Polystyrene

What if we could shine a blue LED on our 8 billion tons of plastic waste and get back a valuable chemical feedstock? Click to read about the Reisner group’s work looking at tackling this problem.

photocatalysis in seawater
Photocatalysis in Seawater

Seawater: It’s abundant, messy, contains salts, microorganisms, biomass, organic and inorganic pollutants (and microplastics) and might just be a great solvent for generating hydrogen peroxide with visible light photocatalysis

Comparing Commercial Photoreactors

How should we compare commercial photoreactors? Or better yet, how do we discuss the important details of a photochemical reaction?

The 21 Must-Read Photochemistry Papers of 2021

Beyond the best photochemistry papers of 2021, read about the amazing year we had here at HepatoChem.

Utilizing the Lucent360 From Screen to Scale

Read on for a step by step study taking a photocatalyzed-Arbuzov reaction from screen to scale utilizing the unique features of the Lucent360™

Introducing the Lucent360

The Lucent360’s flexible design gives you the best options to learn everything you need to know to take your photochemical reactions from screen to scale.

Photochemistry of earth-abundant metals

A recurring theme in our recent articles: there isn’t enough iridium or ruthenium in the earth’s crust to do all the photochemistry we’d like to do at scale.

The Attack of the Photocatalytic Microrobots!

Self-propelled autonomous microrobots that can swim through mazes to seek and destroy microplastics? Read on…

Using Multiphoton Excitation To Generate Potent Photooxidants

Our review of a recent Wickens paper describing the formation of powerful new photooxidants through a mechanism of multiphoton excitation.

Petal Power: Organic Dyes in Photochemistry
Potpourri Catalysis – Fascinating Photoredox Chemistry With Organic Dyes

Add dried flower petals to your photochemistry reaction? This group did. Their paper on photoredox chemistry with organic dyes is brilliant.

Contact Us

Interested in learning more about our products?

Complete our short contact form and we’ll get back to you as soon as possible.

Stay up-to-date!
Get insights and tips from experts