Baran Alkylation-Sulfinate Alkylation Production Kit

Baran Alkylation kit:
Sulfinate Alkylation Production

 6 Different Diversification Groups


Product overview:

The sulfinate alkylation reaction described by Prof. Baran is a powerful late stage functionalization tool. Our kit is available in 2 sizes. A small scale kit to screen the chemistry using multiple solvents (HCK1013-01-002) and a production kit (HCK1013-01-001) to conveniently produce in one step 6 different analogues of a lead compound in mg quantities. Each reaction vial contains sulfinate alkylation reagent (pre-weighed) and a stirring bar to react with your substrate.  C-H functionalization will primarily occur on electron-deficient heteroarenes at one or several positions.


The typical protocol is performed at 0.142 mol/l concentration reaction condition. 2 equivalents of sulfinate reagent are preloaded (100 µmol) and 3 equivalents of TBHP is added. These reaction conditions are not air sensitive.

Recommended solvents are DMSO or CHCl3 with or without H2O/TFA (0.1 ml of TFA in 2 ml of water).  H2O/TFA can change the regioselectivity and conversion of the reaction.

Prepare a solution of substrate with 300 µmol of substrate in 2.1 ml selected solvent.

  • Add 350 µl of substrate solution to each reagent vial containing the sulfinates. Shake the vial to allow reagents to mix properly.
  • If needed add 80 µl of H2O/TFA in each vial.
  • Add 21 µl of TBHP in each vial.
  • Stir the reaction vials in the reaction block at 50°C for 12-24 hours.
  • Remove the vial caps.
  • Prepare analytical sample for each reaction condition with 5 µl sample diluted into 200 µl in either DMSO or water/acetonitrile 50/50.

Analyze resulting analytical samples by LC/MS.



Sulfinate Alkylation Solvent Effect



Substrate: Hydroquinine





TFMS-solvent IPS-solvent
photocatalysis in seawater
Photocatalysis in Seawater

Seawater: It’s abundant, messy, contains salts, microorganisms, biomass, organic and inorganic pollutants (and microplastics) and might just be a great solvent for generating hydrogen peroxide with visible light photocatalysis

Comparing Commercial Photoreactors
When is an apple an apple or when is it an orange? How should we compare commercial photoreactors?  Or better yet, how do we discuss the important details of a...
The 21 Must-Read Photochemistry Papers of 2021
A belated year in review 2021 At HepatoChem, we had a big year in 2021. We started shipping our new photoreactor the Lucent360™, added members to our team, moved...
Utilizing the Lucent360 from screen to scale
A few weeks ago, we discussed the history of the Lucent360™, our new photoreactor for light and temperatures control for screen to scale, in both batch and flow....
Introducing the Lucent360 TM
A Brief History of a PhotoReactor We write from time to time here about the topics that we find interesting or humorous in the photoredox, visible-light photocatalysis...
Photochemistry of earth-abundant metals
A recurring theme for many of our articles over the last few months is that there just isn’t enough iridium or ruthenium in the earth’s crust to do all of the...
The Attack of the Photocatalytic Microrobots!
The attack of the photocatalytic microrobots! We have intended to write a bit about visible-light decomposition of contaminants for a while... so what better entry into...
Using Multiphoton Excitation To Generate Potent Photooxidants
A New Potent Photooxidant Pushing the limits of LED driven visible-light photocatalysis requires some creative thinking to get more redox potential out of the tools...
Petal Power: Organic Dyes in Photochemistry
Potpourri Catalysis – Fascinating Photoredox Chemistry With Organic Dyes
Spring is nearly here in Massachusetts.  The snow has almost completely melted, and the days are getting longer.  Soon the first flowers will bloom and some of those...
sarcastic 2020 logo
The 20 Must Read Photochemistry Papers from 2020
Year in review 2020.  Let’s all agree to not look back.  20 papers for 2020 As the year comes to the close, we thought it was time to have a little fun and look back at...
Photochemistry 101, Part III: Setting Up Your Initial Photochemistry Reactions
Setting Up Your Initial Photochemistry Reactions This is the third and final part of a three part series designed to help you get started by understanding light sources...

Contact Us

Interested in learning more about our products?

Complete our short contact form and we’ll get back to you as soon as possible.

Stay up-to-date!
Get insights and tips from experts