Structure-Activity Relationship of Hepatotoxicity

Drug induced liver injury is a major cause for withdrawing a drug from development or more dramatically from the market. In a recent article, Dr. Dennis J. Pelletier et Al. performed a SAR study of hepatotoxicity. They used the data from literature and built a...

Fluorine and Deuterium to Improve Oral Bioavailability

In a recent article, Dr Angela D. Kerekes et al. described the PK optimization of a potent Aurora inhibitor 1. This compound presents a good PK profile for intravenous delivery but poor oral bioavailability in rats due to rapid metabolism and poor oral absorption....

Are Metabolites Involved in Drug-Drug interaction?

Qualitative Analysis of the Role of Metabolites in Inhibitory Drug-Drug Interactions In a recent guidance, the Food and Drug Administration recommended safety studies of metabolites. This guidance applied primarily to the metabolites formed specifically in humans for...