Palladium based catalysis is the most used tool to perform the formation of C-C, C-O and C-N. There are many sources of palladium such as PdOAc2, PdCl2 or Pd2dba3. However the related methods do not always allow sufficient conversion. Palladium precatalysts is an...
In medicinal chemistry, fluorine substitution of alkyl or aryl hydrogen is an increasingly popular strategy to optimize lead compounds. Fluorine offers unique properties. It is almost as small as a hydrogen but very electronegative. The C-F bond is highly polarized....
Biotransformations can be diverse and not limited to simple oxidation or dealkylation. An oncologic agent, The BMS-690514, is an example of unexpected metabolism. This compound undergoes multiple biotransformations, among them are P450 mediated oxidations of its...
Several recent papers have highlighted the importance of identifying mitochondrial liabilities to completely assess the toxicity potential of a drug (1-3). Mechanisms by which drugs induce organ toxicity include the production of reactive metabolites (4). Examples...
Metalloporphyrins are powerful catalysts capable of a wide variety of chemical transformations. Simple modifications to the catalyst system allow for tuning a catalyst for relatively mild oxidations or more difficult to oxidize substrates. Recently, Zhdankin and...
Drug induced liver injury is a major cause for withdrawing a drug from development or more dramatically from the market. In a recent article, Dr. Dennis J. Pelletier et Al. performed a SAR study of hepatotoxicity. They used the data from literature and built a...
Is it time to expand your lab's photochemistry resources? Interested in upgrading to the most efficient photoreactor on the market? ⚗️🙌🚀
Check out the video below for a short overview of our best-selling photoreactor and its many features...
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Excellent publication for Prof. Alex Cresswell at University of Bath and GSK scientists. Photocatalytic α‐Tertiary Amine Synthesis via C–H Alkylation of Unmasked Primary Amines. #photoreactor#Evoluchemonlinelibrary.wiley.com/doi/a…
Here's an overview of how we perform a ferrioxalate actinometer protocol to determine photon flux in our various photoreactors. We try to go into as much detail as possible so you can replicate these steps in your own lab and with your own equipment.
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Determining Photon Flux in Photochemical Experiments
A few weeks ago, I posted an article from our site on how to evaluate light sources for your photochemical reactions. Next up is determining photon flux!
Check out our new article
hepatochem.com/determine-phot…
