Methyl groups are very common in drug molecules. As reported by Heike Schonherr and Tim Cernak1, more than half of the top-selling drugs contains a CH3. A simple substitution of a C-H with a methyl can increase the potency of a compound by more than 100-fold. The...
Palladium based catalysis is the most used tool to perform the formation of C-C, C-O and C-N. There are many sources of palladium such as PdOAc2, PdCl2 or Pd2dba3. However the related methods do not always allow sufficient conversion. Palladium precatalysts is an...
In medicinal chemistry, fluorine substitution of alkyl or aryl hydrogen is an increasingly popular strategy to optimize lead compounds. Fluorine offers unique properties. It is almost as small as a hydrogen but very electronegative. The C-F bond is highly polarized....
Dr Ryan Buzdygon will be presenting “Late-stage functionalization platform for lead optimization and diversification: Generation of high value compounds directly for biological testing” at ACS Boston. Stop by on Wednesday August 19th during the General Posters Session...
HepatoChem will be present at the tenth annual Drug Discovery Chemistry on April 21-23, 2015 in San Diego. Please come and see us at the booth 34. see more information at http://www.drugdiscoverychemistry.com/
Lenexa, KS, August 19th, 2014 — XenoTech announces an exclusive partnership with HepatoChem to offer fast and cost-effective metabolite production from bioactive small molecules. Based on an innovative and proprietary chemistry platform, the technology...
Always been interested in photochemistry but not sure where to begin? Here's our first post (part of a three-part series) intended to get you comfortable with the core principles and provide you with everything you need to get started!
t.ly/XOhjpic.twitter.com/CRe0NrRP4V
Tomorrow (Sept 12, 2020) is Akira Suzuki's 90th birthday! He is a pioneer of modern chemistry and his famed Suzuki reaction was originally published in 1979, leading to his Nobel Prize in 2010.
Learn more about him at t.ly/VumU
Happy 90th Birthday! pic.twitter.com/BMgcKguIFA
Lewis Latimer was born on this day in 1848. The son of former slaves, he went on to patent a new design for carbon filament production, making incandescent lighting a reality for consumers.
Old School for this #FluorescenceFriday!
t.ly/nJ8mpic.twitter.com/MVBaddtGUy
Congrats to Fabien Legros & Volker Derdau @sanofiDE. Their recent pub outlines a photoredox‐initiated hydrogen atom transfer (HAT) protocol which could efficiently develop radioactive labeled peptides for bioimaging.
lnkd.in/d8Mu635
And, if we may, nice photoreactor! pic.twitter.com/fMFjyPQgGJ
