Amide Coupling in Medicinal Chemistry

In recent years, amide coupling has become the most frequently used reaction in medicinal chemistry1.  Found as the backbone of proteins, the amide bond is nominal formed by the condensation of a carboxylic acid and an amine.  Due to a nearly unlimited set of readily...

PhotoReactor Setup

Interest in photochemistry has been growing exponentially in recent years. Numerous new applications using visible-light photoredox catalysis have been discovered. These catalytic systems can perform many types of bond formations using various substrates which are...

How do you handle hygroscopic salts?

Salts such as weak bases are omnipresent in organic chemistry. The conversion rate of a reaction can be greatly affected depending on the salt. While it is easy to weigh K2CO3 or Na2CO3. Because salts like Cs2CO3 or K3PO4 are hydroscopic salts, they are more difficult...