Alkoxylation & Acetoxylation Opti. Kit:
(HCK1007-01-002)
2 set of 12 reaction conditions. 10 mol% PdOAc2, 1 or 2 equivalents of PhIOAc2with 5 different salts CuOAc2, Ag2CO3, K2CO3, Cs2CO3, and MgSO4 (and no salt).
24 reaction vials total
The typical protocol is performed at 0.1 mol/l concentration reaction condition of substrate, 10 mol% catalyst and 1 or 2
Protocol at 50 µl volume reaction condition
- Prepare
required volume of a 0.1 mol/L solution of substrates inappropriate solvent. For example, 700 µl solution for 12 reaction conditions (100 µl extra to compensate potential evaporation). - Using a clean and dry syringe, add 50 µl of substrate solution to each reaction vial.
- Stir the reaction vials in the reaction block at
desired temperature (forexample: 60°C) for 12-24 hours. - Remove the vial caps using a
decapper . - Prepare
analytical sample for each reaction condition with 5 µl sample diluted into 200 µl in either DMSO or water/acetonitrile 50/50.
Analyze resulting analytical samples by LC/MS.
