Suzuki-Miyaura Coupling Kits

 

Product overview:

The Suzuki-Miyaura coupling kits are ideal tools for the investigation of chemical reaction conditions. This enables to conveniently screen multiple reaction conditions simultaneously using pre-weighed  catalysts and reagents. The kit contains all reagents and supplies to perform the reaction conditions. The selected catalysts are the most commoly used with tetrakis(triphenylphosphine)palladium, [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) (Pd(dppf)2), Palladium(II) acetate and Tris(dibenzylideneacetone)dipalladium(0) (Pd2(dba)3) with XPhos or SPhos ligands.

Benefits
Features
  • Facilitates screen of reaction conditions
  • No glove-box needed to manipulate air sensitive or moisture sensitive reagents
  • Enables up to 32 reaction conditions simultaneously
  • Save substrate using low scale reaction conditions
  • Save time on optimization
  • 0.3 ml crimped vial with stirring bar.
  • Specifically designed reaction block
  • Pre-weighed reagents and catalysts
  • Temperature from 0°C to 120°C
  • Pre-designed or custom arrays available
Standard Protocol:

Substrate solution to be made at 0.15M concentration , 10% catalyst, 2 equivalent of base. 100 µl reaction volume.

Available kits:

HCK1003-01-001: 1 set of 6 catalysts, 4 base solutions and 4 solvents

HCK1003-01-002: 1 set of 8 catalysts, 4 base solutions and 4 solvents

Substrate 15 µmol Base Solutions
Precatalysts 1.5 µmol (10%) Na2CO3 K2CO3 K3PO4 Cs2CO3
Pd(PPh3)4

Primary array

 HCK1003-01-001

 6 catalysts & 4 bases

Pd(dppf)2Cl2
PdOAc2 SPhos
PdOAc2 XPhos
Pd2(dba)3 SPhos
Pd2(dba)3 XPhos
Pd(OAc)2/CataCXium®

 Extended array HCK1003-01-002

8 catalysts & 4 bases

Pd(Amphos)Cl2

Sparged solvents: acetonitrile, dioxane, n-butanol and DMF

Custom kits are available upon request
see available ligands here
Starter kit and refill system
  • Starter kits contain a reaction block specifically designed to hold arrays of reaction conditions. They contain supplies to set-up the reaction conditions.
  • The refills contains the reagents necessary to performed several screening arrays.
for more information contact us at info@hepatochem.com