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Sulfinate Alkylation Diversification Kit |
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Product overview:
The sulfinate alkylation reaction described by Prof. Baran is a powerful late stage functionalization tool. Our kit allows to conveniently produce in one step 6 different analogues of a lead compound in mg quantities. Each reaction vial contains 100 µmol of sulfinate alkylation reagent (pre-weighed) and a stirring bar to react with 50 µmol of substrate. C-H functionalization will primarily occur on electron-deficient heteroarenes at one or several positions.
6 Different Diversification Groups |
Test Compounds |
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Standard Protocol: Several solvents or solvent mixtures can be used to perform the reaction (DMSO, DMSO/H2O/TFA, CHCl3/H2O/TFA… ). A solution of substrate is made with 300 µmol of substrate in 2.1 ml selected solvent. 350 µl is added in each vial followed by 20.8 µl of TBuOOH (70% in water). The reactions are allowed to stir at 50°C for 12-24 hours.
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Kit contents (HCK1013-01-001) : 2 reaction vials of each reagents (100 µmol), 12 reaction vials total
Sulfinate Alkylation Reagents (2 Vials of each) | ||||||
Zinc difluoro methane sulfinate | Zinc trifluoro methane sulfinate | Sodium 1,1-difluoro ethane sulfinate |
Zinc trifluoro ethane sulfinate | Zinc isopropyl sulfinate | Sodium trifluoro propyl sulfinate | |
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MW (g/mol) | 295.55 | 331.53 | 152.10 | 359.58 | 279.69 | 184.11 |
CAS Number | 1355729-38-2 | 39971-65-8 | 1422738-67-7 | 1416821-53-8 | 1416821-55-0 | 1263377-91-8 |
Literature references:
Ming Yan, Julian C. Lo, Jacob T. Edwards, and Phil S. Baran J. Am. Chem. Soc., 2016, 138 (39), pp 12692–12714
Fionn O’Hara, Donna G. Blackmond*, and Phil S. Baran J. Am. Chem. Soc., 2013, 135 (32), pp 12122–12134
For more information contact us at info@HepatoChem
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