First Choice Coupling Reagent Kit

Product overview:

The amide coupling kits are ideal tools for the optimization of amide bond formation. This enables to conveniently screen multiple reaction conditions simultaneously using pre-weighed reagents. We offer pre-selected arrays of reagents and salts or custom arrays depending on your needs.

First choice array:

The first choice array contains a selection of the most representative coupling reagents from the 3 reagent classes; Carboddimide, Aminium and Phosphonium salts. We included ethyl (hydroxyimino)cyanoacetate) which can improve reaction rate. We can also create any custom array that would fit your needs.

Kit Description:

The kit contains vials loaded with 10 µmol of coupling reagent and a stirring bar and two vials containing ethyl (hydroxyimino)cyanoacetate). Reaction can be performed from 0.2 M in 50 µl to 0.05 M in 200 µl at 1/1 ratio acid and coupling reagent.

Catalog Ref# HCK1005-01-007 ; List price $299

 

Features:
  • 0.3 ml crimped vial with stirring bar.
  • Specifically designed reaction block (in the starter kit HCK1006-01-001)
  • Pre-weighed reagents
  • Temperature from 0°C to 50°C
  • Pre-designed or custom arrays available
  • Reagents are packaged under inert atmosphere
Kit contents:
Name CAS Number Quantity Amount
DIC 693-13-0

2x vial

10 µmol

EDC, HCl 25952-53-8

2x vial

10 µmol

HATU 148893-10-1

2x vial

10 µmol

COMU 1075198-30-9

2x vial

10 µmol

PyBOP 128625-52-5

2x vial

10 µmol

DEPBT 165534-43-0

2x vial

10 µmol

ethyl(hydroxyimino) cyanoacetate 3849-21-6

2x vial

70 µmol

Protocol:
hck1005-01-007_process

 

Reagent structures:

 

DICCAS 693-13-0

DIC
CAS 693-13-0

EDCCAS 1892-57-5

EDC
CAS 25952-53-8

 

HATUCAS 148893-10-1

HATU
CAS 148893-10-1

COMUCAS 1075198-30-9

COMU
CAS 1075198-30-9

PyBOPCAS 128625-52-5

PyBOP
CAS 128625-52-5

DEPBTCAS 56602-33-6

DEPBT
CAS 56602-33-6

Ethyl(hydroxyimino) cyanoacetateCAS 3849-21-6

Ethyl(hydroxyimino) cyanoacetate
CAS 3849-21-6

 

For more information contact us at info@hepatochem.com